Circulating adipose-tissue miRNAs in gastrointestinal cancer patients and their association with the level and type of adiposity at body composition analysis

• DOI: 10.3389/fmolb.2024.1449197
• Publication Date: 2024-07-30T04:24:38Z
• Authors: Federica Tambaro; Giovanni Imbimbo; Valentina Pace; Maria Ida Amabile; Veronica Rizzo; Simona Orlando; Giulia Lauteri; Cesarina Ramaccini; Carlo Catalano; Giuseppe Nigri; Maurizio Muscaritoli; Alessio Molfino
• Keywords: adiposity; body composition; 0303 health sciences; 03 medical and health sciences; QH301-705.5; miRNAs; cancer; Molecular Biosciences; CT-scan; Biology (General); cachexia; ct-scan; adiposity; body composition; cachexia; cancer; mirnas

Adipose tissue (AT) wasting in cancer is an early catabolic event with negative impact on outcomes. Circulating miRNAs may promote body weight loss and cachexia. We measured circulating linked to AT alterations compared their levels between i) gastrointestinal (GI) patients controls, ii) cachectic non-cachectic patients, iii) according adiposity level its distribution.