Malnutrition and Risk of Mortality in Ischemic Stroke Patients Treated With Intravenous Thrombolysis

• DOI: 10.3389/fnagi.2022.834973
• Publication Date: 2022-02-21T18:46:45Z
• Authors: Haiyan Tang; Fan Gong; Hongquan Guo; Zheng Dai; Jun Wang; Bin Liu; Tingting Li; Xianbiao Tang; Junru Dong; Song Pan; Mingzhe Wang; Yan Sun; Baofeng Qin; Jingsi Zhang; Xuyin Zhu; Jun Tian; Zhimin Fei; Gendi Lu; Dezhi Liu
• Keywords: Stroke

Malnutrition is highly prevalent in ischemic stroke patients. We aimed to investigate whether malnutrition indexes may be useful predicting mortality at 90 days patients treated with intravenous thrombolysis.We retrospectively analyzed consecutive who underwent thrombolytic therapy three comprehensive centers. was assessed using the controlling nutritional status (CONUT) score, geriatric risk index (GNRI), and prognostic (PNI).Of 979 (mean age, 66.8 years; males, 63.6%) included this study, 91 (9.3%; 95% confidence interval [CI]: 8.4-10.2%) died 3-month follow up. According CONUT, GNRI, PNI scores, 9.9, 33.7, 7.0% of were moderately or severely malnourished, respectively; 64.0% least mildly malnourished by 1 index. In multivariate regression model after adjusting for potential confounders, (severe versus normal status) significantly associated an increased CONUT scores (adjusted odds ratio [OR] 16.16, 95%CI, 7.86-67.11; P < 0.001), GNRI OR 9.82, 4.10-23.51; 0.001) 12.74, 5.56-29.19; 0.001). Similar results found when as continuous variables. Adding models containing conventional factors improved reclassification mortality.Our study showed that a higher 3 months thrombolysis.