Systemic-Immune-Inflammation Index as a Promising Biomarker for Predicting Perioperative Ischemic Stroke in Older Patients Who Underwent Non-cardiac Surgery

• DOI: 10.3389/fnagi.2022.865244
• Publication Date: 2022-03-31T20:59:33Z
• Authors: Faqiang Zhang; Mu Niu; Long Wang; Yanhong Liu; Likai Shi; Jiangbei Cao; Weidong Mi; Yulong Ma; Jing Liu
• Keywords: Interquartile range; Stroke

This study aimed to investigate the clinical prognostic values of preoperative systemic-immune-inflammation index (SII) in older patients undergoing non-cardiac surgery, using perioperative ischemic stroke as primary outcome.This retrospective cohort included who underwent surgery between January 2008 and August 2019. The were divided into SII < 583 ≥ group according optimal cut-off value. outcome interest was within 30 days after surgery. Primary, sensitivity, subgroup analyses performed confirm that qualifies a promising, independent indicator. Propensity score matching (PSM) analysis further applied address potential residual confounding effect covariates examine robustness our results.Among 40,670 with median age 70 years (interquartile range: 67, 74), 237 (0.58%) experienced an associated increased risk multivariate regression [odds ratio (OR), 1.843; 95% confidence interval (CI), 1.369-2.480; P 0.001]. After PSM adjustment, all well balanced two groups. correlation remained significantly robust (OR: 2.195; CI: 1.574-3.106; 0.001) analysis.Preoperative SII, which includes neutrophil, platelet, lymphocyte counts obtained from routine blood analysis, biomarker for predicting elderly patients. An elevated based on value 583, factor stroke.