Theta and gamma oscillations in the rat hippocampus support the discrimination of object displacement in a recognition memory task

• DOI: 10.3389/fnbeh.2022.970083
• Publication Date: 2022-12-21T08:37:25Z
• Authors: Lívia Neves; Bruno Lobão-Soares; Ana Paula de Cast...; Alan Michel Bezer...; Izabela Paiva; Nicholy Souza; Anne Kelly Morais; George Nascimento; Elaine Gavioli; Adriano Bretanha ...; Flávio Freitas Ba...; Hindiael Belchior
• Keywords: Local field potentials; hippocampus; Neurosciences. Biological psychiatry. Neuropsychiatry; Spatial displacement of objects; local field potentials; recognition memory; Hippocampus; Recognition memory; 03 medical and health sciences; spatial displacement of objects; 0302 clinical medicine; Pattern separation; pattern separation; Recognition - psychology; RC321-571; Neuroscience

Episodic memory depends on the recollection of spatial and temporal aspects past experiences in which hippocampus plays a critical role. Studies hippocampal lesions rodents have shown that dentate gyrus (DG) CA3 are necessary to detect object displacement tasks. However, understanding real-time oscillatory activity underlying discrimination subtle pronounced displacements remains elusive. Here, we chronically implanted microelectrode arrays adult male Wistar rats record network oscillations from DG, CA3, CA1 dorsal while animals executed an recognition task high low tests (HD: 108 cm, LD: 54 respectively). Behavioral analysis showed discriminate between stationary displaced objects HD but not LD conditions. To investigate hypothesis theta gamma different areas support processes task, compared epochs exploration conditions as well objects. We observed were accompanied by strong rhythmic frequency (6-12 Hz) band three areas. Comparison test revealed higher power theta-gamma phase-amplitude coupling DG during than Similarly, direct comparison within Moreover, index directly correlated with exploration. thus conclude successful task.