Integrative Functional Transcriptomic Analyses Implicate Shared Molecular Circuits in Sensorineural Hearing Loss

• DOI: 10.3389/fncel.2022.857344
• Publication Date: 2022-03-14T10:36:20Z
• Authors: Peng Chen; Jun-Jun Hao; Meng-Wen Li; Jing Bai; Yuan-Ting Guo; Zhen Liu; Peng Shi
• Keywords: Ototoxicity

Sensorineural hearing loss (SNHL) is referred to as the most common type of and typically occurs when inner ear or auditory nerve damaged. Aging, noise exposure, ototoxic drugs represent three main causes SNHL, leading substantial similarities in pathophysiological characteristics cochlear degeneration. Although molecular mechanisms are widely assumed underlie these similarities, its validity lacks systematic examination. To address this question, we generated SNHL mouse models from aging, cisplatin ototoxicity, respectively. Through constructing gene co-expression networks for transcriptome data across different hearing-damaged stages, found significantly correlate with each other multiple modules that implicate distinct biological functions, including apoptosis, immune, inflammation, ion transport. Bioinformatics analyses reveal several potential hub regulators, such IL1B CCL2, both which verified contribute apoptosis accompanied by increase (ROS) vitro model system. Our findings disentangle shared circuits types providing targets broad effective therapeutic agents SNHL.