Effects of Deep Brain Stimulation in the Subthalamic Nucleus on Neurocognitive Function in Patients With Parkinson's Disease Compared With Medical Therapy: A Meta-Analysis

• DOI: 10.3389/fneur.2021.610840
• Publication Date: 2021-03-02T05:27:40Z
• Authors: Jiazhen Wang; Ru Pan; Ying Cui; Zhigang Wang; Qinghua Li
• Keywords: Neurocognitive; Verbal fluency test; Subthalamic Nucleus; Affect

Background: DBS has been shown to significantly affect motor symptoms in Parkinson's disease (PD). However, some studies have suggested that it may adverse effects on patients' neurocognitive function. To clarify this operation's effect function, we collected containing function evaluation for qualitative and quantitative analysis. Methods: We searched relevant clinical through Pubmed Embase databases extracted sorted out information such as sample size, post-operative scores, pre-operative interval, PD course, exclusion criteria, from articles meeting the standards. The magnitude variance of group's combined drug therapy group each domain were calculated analyzed by random-effects model. Results: Compared with treatment group, verbal fluency patients experimental was decreased at least moderately (ES = −0.553), which phonemic declines greatly −0.842), learning memory ability slightly −0.305), other functions not decreased. Conclusion: STN-DBS can damage memory. There no significant correlation between above progression itself, more likely be associated STN-DBS. It is should trained evaluated regularly their ability. safety acceptable majority symptoms.