Penumbra Detection With Oxygen Extraction Fraction Using Magnetic Susceptibility in Patients With Acute Ischemic Stroke

• DOI: 10.3389/fneur.2022.752450
• Publication Date: 2022-02-11T05:34:21Z
• Authors: Yuto Uchida; Hirohito Kan; Hiroyasu Inoue; Masahiro Oomura; Haruto Shibata; Yuya Kano; Tomoyuki Kuno; Toshihiko Usami; Koji Takada; Kentaro Yamada; Kohsuke Kudo; Noriyuki Matsukawa
• Keywords: Penumbra; Stroke

The oxygen extraction fraction (OEF) has been applied to identify ischemic penumbral tissue, but is difficult use in an urgent care setting. This study aimed investigate whether OEF map generated via magnetic resonance quantitative susceptibility mapping (QSM) could help the penumbra patients with acute stroke.This prospective imaging included 21 large anterior circulation vessel occlusion who were admitted <24 h after stroke onset and age-matched healthy controls. We identified as region a Tmax of >6 s during dynamic contrast-magnetic (DSC-MRI) calculated perfusion-core mismatch ratio between infarct core volumes. values measured based on differences venous structures brain tissues using rapid QSM acquisition. Volumes increased compared volumes anatomical template.Eleven had ≥1.8, reperfusion therapy was recommended. In these patients, >51.5%, which defined territory from controls, positively correlated (r = 0.636, 95% CI: 0.059 0.895, P 0.035) inversely 30-day change National Institutes Health Stroke Scale scores -0.624, -0.891 -0.039, 0.041).Tissue predict DSC-MRI, highlighting potential QSM-derived biomarker guide treatment selection stroke.