Case Report: A Case of Concomitant Paroxysmal Kinesigenic Dyskinesia and Epilepsy: Can We Treat Two Birds With One Stone?

• DOI: 10.3389/fneur.2022.826897
• Publication Date: 2022-02-02T05:09:56Z
• Authors: Jun-Hong Geng; Yang Zheng; Quan-Fu Li; Qun Hou; Xiao-Hang Wang; Yan Jiang
• Keywords: Paroxysmal dyskinesia; Lacosamide; Levetiracetam; Concomitant; Oxcarbazepine; Valproic Acid

Background Paroxysmal kinesigenic dyskinesia (PKD) is characterized by recurrent episodes of movement-induced motor attacks. PKD patients may have concomitant epilepsy. Differentiation between the two disorders and effective control both diseases remain challenging. Case Presentation We present a Chinese girl with typical manifestations PKD, who also suffered from generalized tonic-clonic seizure attacks at same time. Genetic testing confirmed PRRT2 mutation (c.649dupC). Oxcarbazepine was initially used, but withdrawn due to hypersensitivity reaction. Levetiracetam initiated afterwards, which for seizures failed her symptoms. The addition lacosamide (LCM) completely controlled Conclusion This first case reporting effectiveness LCM Our proposes novel alternative such are resistant or cannot tolerate conventional anti-sodium antiepileptics.