Vagus nerve stimulation for refractory posttraumatic epilepsy: Efficacy and predictors of seizure outcome

• DOI: 10.3389/fneur.2022.954509
• Publication Date: 2022-07-28T09:37:26Z
• Authors: Mengyi Guo; Jing Wang; Chongyang Tang; Jiahui Deng; Jing Zhang; Zhonghua Xiong; Siqi Liu; Yuguang Guan; Jian Zhou; Feng Zhai; Guoming Luan; Tianfu Li
• Keywords: Vagus Nerve Stimulation; Refractory (planetary science)

Background Traumatic brain injury (TBI) has been recognized as an important and common cause of epilepsy since antiquity. Posttraumatic (PTE) is usually associated with drug resistance poor surgical outcomes, thereby increasing the burden illness on patients their families. Vagus nerve stimulation (VNS) adjunctive treatment for medically refractory epilepsy. This study aimed to determine efficacy VNS PTE initially evaluate potential predictors efficacy. Methods We retrospectively collected outcomes at least a 1-year follow-up in all PTE. Subgroups were classified responders non-responders according (≥50% or <50% reduction seizure frequency). Preoperative data analyzed screen Results In total, forty-five who underwent therapy enrolled. Responders found 64.4% patients, 15.6% achieved freedom last follow-up. addition, responder rate increased over time, 37.8, 44.4, 60, 67.6% 3-, 6-, 12-, 24-month follow-ups, respectively. After multivariate analysis, generalized interictal epileptic discharges (IEDs) be negative predictor (OR: 4.861, 95% CI: 1.145–20.632) Conclusion The results indicated that was effective well tolerated period. Patients focal multifocal IEDs have better after therapy.