COMIRESTROKE—A clinical study protocol for monitoring clinical effect and molecular biological readouts of COMprehensive Intensive REhabilitation program after STROKE: A four-arm parallel-group randomized double blinded controlled trial with a longitudinal design

• DOI: 10.3389/fneur.2022.954712
• Publication Date: 2022-11-01T06:46:16Z
• Authors: Kamila Řasová; Patrícia Martinková; Michaela Vařejková; Barbora Miznerová; Markéta Pavlíková; Jana Hlinovská; David Hlinovský; Štěpánka Philippová; Michal Novotný; Karolína Pospíšilová; Paula Biedková; Romana Vojíková; Jan Havlík; Valerie Bríd O'Leary; Marie Černá; Aleš Bartoš; Tom Philipp
• Keywords: Stroke; Neurorehabilitation; Facilitation

While the role of physiotherapy as part a comprehensive inpatient rehabilitation is indisputable, clear evidence concerning effectiveness different managements [interdisciplinary implementing International Classification Functioning, disability and health (ICF) vs. multidisciplinary model] categories (neuroproprioceptive "facilitation, inhibition" motor/skill acquisitions using technologies) are still lacking. In this study, four kinds with management content physical therapy will be compared. Moreover, focus placed on identification novel biological molecules reflective effective rehabilitation. Long non-coding RNAs (lncRNAs) transcripts (>200 bps) limited coding potential, which have recently been recognized key factors in neuronal signaling pathways ischemic stroke such, may provide valuable readout patient recovery neuroprotection during therapeutic progression.Adults after first an early sub-acute phase motor randomly assigned to one groups undergo 3 weeks types: interdisciplinary team work ICF model guide; teamwork neuroproprioceptive "facilitation physiotherapy; technology-based standard teamwork. Primary (the Goal Attainment Scale, Patient-Reported Outcomes Measurement Information System, World Health Organization Disability Assessment Schedule) secondary (motor, cognitive, psychological, speech swallowing functions, functional independence) outcomes measured. A blood sample obtained upon consent (20 mls; representing pre-rehabilitation molecular) before program. followed up again 12 months end The overarching aim study determine various physiotherapeutic implemented by patients post via analysis primary, long RNA readouts. This clinical trial offer innovative approach not previously tested new complex along public assessable molecular methodology for alleviation effects stroke.NCT05323916, https://clinicaltrials.gov/ct2/show/NCT05323916.