Effects of cerebellar transcranial direct current stimulation on rehabilitation of upper limb motor function after stroke

• DOI: 10.3389/fneur.2023.1044333
• Publication Date: 2023-03-16T05:32:50Z
• Authors: Qiuwen Gong; Rubing Yan; Han Chen; Xia Duan; Xiaoyu Wu; Xin Zhang; Yi Zhou; Zhou Feng; Ya Chen; Jianbo Liu; Peng Xu; Jing Qiu; Hongliang Liu; Jingming Hou
• Keywords: Transcranial Direct Current Stimulation; Stroke; Brain stimulation

The cerebellum is involved in the control and coordination of movements but it remains unclear whether stimulation could improve recovery upper limb motor function. Therefore, this study aimed to explore cerebellar transcranial direct current (tDCS) therapy promote function patients who suffered a stroke.In randomized, double-blind, sham-controlled prospective study, 77 stroke were recruited randomly assigned tDCS group (n = 39) or 38). received anodal (2 mA, 20 min) sham for 4 weeks. primary outcome was change Fugl-Meyer Assessment-Upper Extremity (FMA-UE) score from baseline first day after weeks treatment (T1) 60 days (T2). secondary outcomes FMA-UE response rates assessed at T1 T2. Adverse events (AEs) related also recorded.At T1, mean increased by 10.7 points [standard error (SEM) 1.4] 5.8 (SEM 1.3) (difference between two groups 4.9 points, P 0.013). At T2, 18.9 2.1) 12.7 (the difference 6.2 0.043). 26 (70.3%) had clinically meaningful compared 12 (34.3%) 36.0%, =0.002). 33 (89.2%) with 19 (54.3%) 34.9%, 0.001). There no statistically significant incidence adverse groups. In subgroup analysis different hemiplegic sides, rehabilitation effect right hemiplegia better than that left (P < 0.05); age analysis, did not show > 0.05).Cerebellar can be used as an effective safe patients.ChiCTR.org.cn, identifier: ChiCTR2200061838.