Cognitive inhibition deficit in long COVID-19: An exploratory study

• DOI: 10.3389/fneur.2023.1125574
• Publication Date: 2023-04-14T05:32:40Z
• Authors: Jacob Saucier; Caroline Jose; Zaynab Beroual; Mohammad Al-Qadi; Simon Chartrand; Eméraldine Libert; Marie-Claire Losier; Kendra Cooling; Gabriel Girouard; Jalila Jbilou; Ludivine Chamard-...
• Keywords: Neurocognitive; Cognitive deficit; Depression

Background and objectives An increasing number of research studies point toward the importance prevalence long-term neurocognitive symptoms following infection with COVID-19. Our were to capture cognitive impairments from 1 16 months post-COVID-19 infection, assess changes in neuropsychological functions over time, identify factors that can predict deficits cognition. Methodology A cross-sectional design was adopted compare four sub-samples recruited a 16-month timeframe (1–4, 5–8, 9–12, 13–16 months). Phone interviews conducted at least 6 weeks after being infected by Sociodemographic clinical questionnaires administered followed standardized psychological tests health screening symptoms, anxiety, depression, fatigue, autonomy. Results Regarding general questionnaires, 55.2% 134 participants had psychiatric illness, while 21.6% patients moderate-to-severe anxiety or depression. Cognitive efficiency diminished 19.4% our population. Executive dysfunction screened 56% patients, an impairment flexibility inhibition revealed 38.8%. Depression, hospital intensive care unit (ICU) admission, duration ICU stay associated deficit. The elapsed initial assessment not decrease impairments, other than deficit, tended during study period. Discussion This supports extensive literature on neuropsychiatric sequelae COVID-19 highlights long-lasting deficits, seemed improve time. severity could interact as catalyst complex interplay between depression executive functions. absence relation sociodemographic medical reinforces need for all patients. Future should focus longitudinally progression this impairment.