Aberrant age-related alterations in spontaneous cortical activity in participants with cerebral palsy

• DOI: 10.3389/fneur.2023.1163964
• Publication Date: 2023-07-13T19:30:17Z
• Authors: Hannah Bergwell; Michael P. Trevarrow; Elizabeth Heinric...; Anna Reelfs; Lauren R. Ott; Samantha H. Penhale; Tony W. Wilson; Max J. Kurz
• Keywords: Cortical neurons

Cerebral Palsy (CP) is the most common neurodevelopmental motor disability, resulting in life-long sensory, perception and impairments. Moreover, these impairments appear to drastically worsen as population with CP transitions from adolescents adulthood, although underlying neurophysiological mechanisms remain poorly understood. We began address this knowledge gap by utilizing magnetoencephalographic (MEG) brain imaging study how amplitude of spontaneous cortical activity (i.e., resting state) altered during transition period a cohort 38 individuals spastic diplegic (Age range = 9.80-47.50 years, 20 females) 67 neurotypical controls (NT) 9.08-49.40 Females 27). MEG data five-minute eyes closed resting-state paradigm were source imaged, power within delta (2-4 Hz), theta (5-7 alpha (8-12 beta (15-29 gamma (30-59 Hz) frequency bands computed. For both groups, decreased bilateral temporoparietal superior parietal regions age, while alpha, beta, band increased temporoparietal, frontoparietal premotor age. also found significant group x age interaction, such that participants demonstrated significantly less age-related increases sensorimotor cortices compared NT controls. Overall, results demonstrate neural has an trajectory when transitioning adulthood. suggest differences may play critical role aberrant actions seen patient group, provide marker for assessing effectiveness current treatment strategies are directed at improving mobility CP.