Prevalence of neurocognitive disorder in Huntington’s disease using the Enroll-HD dataset

• DOI: 10.3389/fneur.2023.1198145
• Publication Date: 2023-07-14T15:17:55Z
• Authors: Luis A. Sierra; Clementina J. Ullman; Clara Baselga-Gar...; Sarbesh R. Pandeya; Samuel A. Frank; Simon Laganiere
• Keywords: Neurocognitive

Background Cognitive decline in Huntington’s disease (HD) begins early the course, however reported prevalence and severity of cognitive impairment varies based on diagnostic approach. A Movement Disorders Society Task Force recently endorsed use standardized DSM-5-based criteria to diagnose neurocognitive disorder (NCD) disease. Objectives To determine across different stages HD by applying NCD (mild major) participant data from Enroll-HD database. Methods participants were triaged into either premanifest (preHD), manifest or control groups. PreHD was further dichotomized preHD near far predicted time diagnosis using scaled CAG-age product score (CAPs). Embedded performance functional independence measures used for all Results Prevalence NCD-mild 25.2%–38.4% HD, 22.8%–47.3% near, 11.5%–25.1% far, 8.8%–19.1% controls. NCD-major 21.1%–57.7% 0.5%–16.3% 0.0%–4.5% 0.0%–3.0% Conclusion The is elevated demonstrates a sharp rise prior diagnosis. In vast majority meet NCD. These findings are important optimizing clinical care and/or anticipating need supportive services.