A long-term follow-up study of adults with Chiari malformation type I combined with syringomyelia

• DOI: 10.3389/fneur.2023.1274971
• Publication Date: 2023-12-02T21:11:43Z
• Authors: Yan Hu; Mingchu Zhang; Chengcheng Duan; Dengpan Song; Mingkun Wei; Fuyou Guo
• Keywords: Syrinx (medicine); Chiari Malformation

Background There is a considerable amount of controversy regarding the treatment and prognosis adult patients with Chiari malformation type I (CM-I) at home abroad; furthermore, no large-sample, long-term, follow-up studies have examined CM-I syringomyelia (SM) comparing posterior fossa decompression resection tonsils (PFDRT) vs. duraplasty (PFDD). Objective This study retrospectively analyzed factors affecting long-term adults combined SM. Methods We data from 158 SM who underwent PFDRT or PFDD, including 68 in group 90 PFDD. clinical manifestations, imaging features, patients. Clinical outcomes were assessed using Chicago Outcomes Scale (CCOS), radiographic indicated by syrinx remission rate. Multivariate logistic regression analysis multiple linear used to explore relevant Results showed that compared preoperative PFDD group, sensory impairment, cough-related headache, movement disorder significantly improved ( p < 0.01); meanwhile, diameter volume decreased 0.001). Additionally, found there significant differences rate = 0.032) cure rates 0.003) between two groups. age 0.021), cerebellar-related symptoms 0.044), cisterna magna 0.043), peak systolic velocity 0.036) independent for outcomes. Multiple different surgical procedures positively correlated 0.014), while 0.018) 0.002) negatively Conclusion In conclusion, this suggested that, follow-up, although both are effective treating SM, better than PFDD; signs independently affect patient’s prognosis. an evaluation index can be developed patients, which based on characteristics, such as volume, diameter, cerebrospinal fluid (CSF) hydrodynamic parameters guide work.