The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort

• DOI: 10.3389/fneur.2023.1291020
• Publication Date: 2023-12-01T12:07:35Z
• Authors: Sanjula D. Singh; Tin Oreskovic; Sinclair Carr; Keren Papier; Megan Conroy; Jasper R. Senff; Zeina Chemali; Leidys Gutierrez-...; Livia Parodi; Ernst Mayerhofer; Sandro Marini; Courtney Nunley; Amy Newhouse; An Ouyang; H. Bart Brouwers; Brandon Westover; Cyprien Rivier; Guido Falcone; Virginia Howard; George Howard; Aleksandra Pikula; Sarah Ibrahim; Kevin N. Sheth; Nirupama Yechoor; Ronald M. Lazar; Christopher D. An...; Rudolph E. Tanzi; Gregory Fricchione; Thomas Littlejohns; Jonathan Rosand
• Keywords: Stroke

Introduction The 21-point Brain Care Score (BCS) was developed through a modified Delphi process in partnership with practitioners and patients to promote behavior changes lifestyle choices order sustainably reduce the risk of dementia stroke. We aimed assess associations BCS incident Methods derived from United Kingdom Biobank (UKB) baseline evaluation for participants aged 40–69 years, recruited between 2006–2010. Associations subsequent stroke were estimated using Cox proportional hazard regressions, adjusted sex assigned at birth stratified by age groups baseline. Results (median: 12; IQR:11–14) 398,990 UKB (mean age: 57; females: 54%). There 5,354 cases 7,259 recorded during median follow-up 12.5 years. A five-point higher associated 59% (95%CI: 40-72%) lower among <50. Among those 50–59, figure 32% 20-42%) 8% 2-14%) >59 48% 39-56%) <50, 52% (95%CI, 47-56%) 33% 29-37%) >59. Discussion has clinically relevant statistically significant approximately 0.4 million UK people. Future research includes investigating feasibility, adaptability implementation providers worldwide.