Effectiveness and safety of auricular acupuncture on adjuvant analgesia in patients with total knee arthroplasty: a randomized sham-controlled trial

• DOI: 10.3389/fneur.2024.1275192
• Publication Date: 2024-02-16T04:56:04Z
• Authors: Xingshuo Zhang; Hao Chen; Jingqiao Li; Xingang Liu; Xuesong Wang; Pingju Xue; Miao Lin; Jidong Li; Yanfen She
• Keywords: Erythrocyte sedimentation rate

Objective This study aimed to evaluate the effectiveness and safety of auricular acupuncture (AA) on postoperative analgesia, degree nausea, effect inflammation after total knee arthroplasty (TKA). Methods was a single-center, placebo-controlled, randomized clinical trial. In total, 96 patients were randomly divided into an AA group with indwelling intradermal needle ( n = 48) sham (SAA) non-penetrating placebo 48). Intra-spinal anesthesia adopted in both groups during surgery, epidural analgesic pump implanted surgery for 48 h. The primary outcome post-surgery visual analog score (VAS) resting movement states (at 6, 12 h 1, 2, 3, 5, 7 days). secondary outcomes included additional doses injection treatment, C-reactive protein (CRP) levels, erythrocyte sedimentation rate (ESR), white blood cell (WBC) count 1st, 3rd, 7th day operation, nausea 2nd, 3rd Hospital Special Surgery Knee Score (HSS) 2nd 12th week adverse events. Results VAS at 6 h, 5 days lower than those SAA p < 0.05). Among outcomes, dose that serum CRP 1st operation There no significant difference other > Conclusion this study, shown be effective safe complementary alternative therapy pain relief TKA, which able reduce painkillers, decrease 1 improve nausea. Clinical trial registration www.chictr.org.cn , ChiCTR2100054403.