Cholinergic-Induced Specific Oscillations in the Medial Prefrontal Cortex to Reverse Propofol Anesthesia

• DOI: 10.3389/fnins.2021.664410
• Publication Date: 2021-05-26T04:34:45Z
• Authors: Lieju Wang; Weijie Zhang; Ying Wu; Yibo Gao; Na Sun; Hao Ding; Jinxuan Ren; Lina Yu; Liangliang Wang; Fen Yang; Wang Xi; Min Yan
• Keywords: 03 medical and health sciences; 0302 clinical medicine; cholinergic; emergence; Neurosciences. Biological psychiatry. Neuropsychiatry; optogenetic; general anesthesia; basal forebrain; glutamatergic; RC321-571; Neuroscience

General anesthesia is a drug-induced reversible state comprised of altered states consciousness, amnesia, analgesia, and immobility. The medial frontal cortex (mPFC) has been discovered to modulate the level consciousness through cholinergic glutamatergic pathways. optogenetic tools combined with in vivo electrophysiological recording were used study neural oscillatory modulation mechanisms mPFC underlying loss (LOC) emergence. We found that activation both neurons basal forebrain (BF) reversed hypnotic effect propofol accelerated emergence from propofol-induced unconsciousness. light-activation during increased power β (12–20 Hz) low γ (20–30 bands. Conversely, at less specific broad (1–150 cholinergic-induced alteration bands after LOC had opposite effects propofol. These results suggested system might act on more cortical circuits related anesthesia.