Long-Term Overconsumption of Sugar Starting at Adolescence Produces Persistent Hyperactivity and Neurocognitive Deficits in Adulthood

• DOI: 10.3389/fnins.2021.670430
• Publication Date: 2021-06-07T07:11:42Z
• Authors: Kate Beecher; Ignatius Alvarez ...; Joshua Wang; Shaun B. Walters; Fatemeh Chehrehasa; Selena E. Bartlett; Arnauld Belmer
• Keywords: Overconsumption; Neurocognitive; Sugar consumption

Sugar has become embedded in modern food and beverages. This led to overconsumption of sugar children, adolescents, adults, with more than 60 countries consuming four times (>100 g/person/day) the WHO recommendations (25 g/person/day). Recent evidence suggests that obesity impulsivity from poor dietary habits leads further processed The long-term effects on cognitive processes hyperactivity overconsumption, beginning at adolescence are not known. Using a well-validated mouse model consumption, we found level significantly augments weight gain, elicits an abnormal hyperlocomotor response novelty alters both episodic spatial memory. Our results similar those reported attention deficit disorders. deficits hippocampal-dependent learning memory were accompanied by altered hippocampal neurogenesis, overall decrease proliferation differentiation newborn neurons within dentate gyrus. sugar, as which occurs Western Diet might contribute increased risk developing persistent neurocognitive adulthood.