Differential Effects of Pathological Beta Burst Dynamics Between Parkinson’s Disease Phenotypes Across Different Movements

• DOI: 10.3389/fnins.2021.733203
• Publication Date: 2021-11-11T06:06:01Z
• Authors: Raumin S. Neuville; Matthew N. Petrucci; Kevin B. Wilkins; Ross W. Anderson; Shannon L. Hoffman; Jordan E. Parker; Anca Velisar; Helen M. Bronte-S...
• Keywords: BETA (programming language); Dynamics

Background: Resting state beta band (13-30 Hz) oscillations represent pathological neural activity in Parkinson's disease (PD). It is unknown how the peak frequency or dynamics of may change among fine, limb, and axial movements different phenotypes. This will be critical for development personalized closed loop deep brain stimulation (DBS) algorithms during states. Methods: Subthalamic (STN) local field potentials (LFPs) were recorded from a sensing neurostimulator (Activa® PC + S, Medtronic PLC.) fourteen PD participants (six tremor-dominant eight akinetic-rigid) off medication/off STN DBS 30 s repetitive alternating finger tapping, wrist-flexion extension, stepping place, free walking. Beta power peaks burst identified by custom compared movement tasks between akinetic-rigid groups. Results: evident 98% trials; frequencies similar each type movement. Burst duration significantly larger high band, but not low group to group. Conclusion: The conservation states supports feasibility patient-specific driven same activities. Akinetic-rigid had greater longer durations than movement, which relate difference underlying pathophysiology