Triggering Receptor Expressed on Myeloid Cells 2 Protects Dopaminergic Neurons by Promoting Autophagy in the Inflammatory Pathogenesis of Parkinson’s Disease

• DOI: 10.3389/fnins.2021.745815
• Publication Date: 2021-11-18T05:07:11Z
• Authors: Wei Huang; Qiankun Lv; Yunfei Xiao; Zhen Zhong; Binbin Hu; Si Yan; Yufang Yan; Junjun Zhang; Ting Shi; Lijuan Jiang; Wen Li; Guohui Lu
• Keywords: TREM2; Pathogenesis

Parkinson's disease is a neurodegenerative disorder with an inflammatory response as the core pathogenic mechanism. Previous human genetics findings support view that loss of TREM2 function will aggravate neurodegeneration, and one most highly expressed receptors in microglia. However, role mechanism PD not clear. In our study, it was found both