Renal Function and Body Mass Index Contribute to Serum Neurofilament Light Chain Levels in Elderly Patients With Atrial Fibrillation

• DOI: 10.3389/fnins.2022.819010
• Publication Date: 2022-04-14T11:50:07Z
• Authors: Alexandros A. Pol...; Fabrice Helfenstein; Pascal Benkert; Stefanie Aeschbacher; David Leppert; Michael Coslovsky; Eline Willemse; Sabine Schaedelin; Manuel R. Blum; Nicolas Rodondi; Tobias Reichlin; Giorgio Moschovitis; Jens Wuerfel; Gian Marco De Mar...; Stefan T. Engelter; Philippe A. Lyrer; David Conen; Michael Kühne; Stefan Osswald; Leo H. Bonati; Jens Kuhle
• Keywords: 0301 basic medicine; glomerular filtration rate; renal function; 610 Medicine & health; body mass index; Neurosciences. Biological psychiatry. Neuropsychiatry; elderly; 03 medical and health sciences; 0302 clinical medicine; 360 Social problems & social services; neurofilament light; atrial fibrillation; RC321-571; Neuroscience

Serum neurofilament light chain (sNfL) is increasingly used as a neuroaxonal injury biomarker in the elderly. Besides age, little known about how other physiological factors like renal function and body mass index (BMI) alter its levels. Here, we investigated association of estimated glomerular filtration rate (eGFR) BMI with sNfL large sample elderly patients atrial fibrillation (AF).This cross-sectional analysis from Swiss-AF Cohort (NCT02105844). We measured using an ultrasensitive single-molecule array assay. calculated eGFR chronic kidney disease epidemiology collaboration (CKD-EPI) creatinine (eGFRcrea) creatinine-cystatin C (eGFRcrea-cys) formulas, weight height measurements. evaluated role determinants levels multivariable linear regression adjusted R2 (R2adj).Among 2,277 participants (mean age 73.3 years), eGFRcrea showed inverse curvilinear after adjustment for cardiovascular comorbidities. also independent, sNfL. The R2adj models eGFRcrea, alone was 0.26, 0.35, 0.02, respectively. A model combined explained 45% variance. Sensitivity analyses (i) further adjusting vascular brain lesions (N = 1,402 MRI) (ii) eGFRcrea-cys yielded consistent results.In AF cohort, both were associated sNfL, but only substantial proportion This should be taken into account when or disease.