APOE ε4 Allele Distribution and Association With Scores of Subjective Cognitive Decline Questionnaire 9 in a Large Chinese Memory Clinic Cohort

• DOI: 10.3389/fnins.2022.829031
• Publication Date: 2022-06-03T10:00:35Z
• Authors: Lixiao Hao; Jianguo Jia; Yue Xing; Ying Han
• Keywords: Apolipoprotein E; Cognitive Decline; Association (psychology); Memory clinic

Previous reports on APOE ε4 allele distribution in different populations have been inconclusive. The Subjective Cognitive Decline-Questionnaire 9 (SCD-Q9) was developed to identify those at risk of objective cognitive impairment [OCI; including mild (MCI) and dementia groups), but its association with discriminatory powers for SCD subtle decline (SCDs) OCI memory clinics are unclear.To investigate demographic ε4, SCD-Q9 scores, ability discriminate SCDs groups from normal control (NC).A total 632 participants were recruited (NC = 243, 298, 91). scores calculated the effects analyzed. Receiver operating characteristic (ROC) analysis applied NC, SCDs, OCI.Total frequency 13.1%. This did not vary by demography higher patients OCI. carriers than non-carriers group. area under curve (AUC) discriminating using 0.587 0.575, 0.738 0.571 NC groups, respectively. When we combined into model, AUC increased 0.747 NC. However, when group split MCI only score independent affecting factor MCI.This study demonstrated that alleles characteristics a large-scale cohort clinic. may be associated reflecting degree complaints their additional contribution is marginal between