Alterations of Cerebral Perfusion and Functional Connectivity in Children With Idiopathic Generalized Epilepsy

• DOI: 10.3389/fnins.2022.918513
• Publication Date: 2022-06-13T05:08:20Z
• Authors: Guiqin Chen; Jie Hu; Haifeng Ran; Lei Nie; Wenying Tang; Xuhong Li; Qinhui Li; Yulun He; Junwei Liu; Ganjun Song; Gaoqiang Xu; Heng Liu; Tijiang Zhang
• Keywords: Idiopathic generalized epilepsy

Studies have demonstrated that adults with idiopathic generalized epilepsy (IGE) functional abnormalities; however, the neuropathological pathogenesis differs between and children. This study aimed to explore alterations in cerebral blood flow (CBF) connectivity (FC) comprehensively elucidate mechanisms of IGE children.We obtained arterial spin labeling (ASL) resting state magnetic resonance imaging data 28 children 35 matched controls. We used ASL determine differential CBF regions IGE. A seed-based whole-brain FC analysis was performed for significant changes. The mean brain areas group differences extracted, then its correlation clinical variables analyzed by using Pearson analysis.Compared controls, had abnormalities were mainly observed right middle temporal gyrus, occipital gyrus (MOG), superior frontal (SFG), left inferior (IFG), triangular part IFG (IFGtriang). IFGtriang calcarine fissure (CAL) MOG bilateral CAL decreased SFG correlated age at onset. duration.This found altered simultaneously combination may provide additional information insight regarding pathophysiology from neuronal vascular integration perspectives.