Correlation Between Serum High-Sensitivity C-Reactive Protein, Tumor Necrosis Factor-Alpha, Serum Interleukin-6 and White Matter Integrity Before and After the Treatment of Drug-Naïve Patients With Major Depressive Disorder

• DOI: 10.3389/fnins.2022.948637
• Publication Date: 2022-07-13T07:56:20Z
• Authors: Liping Chen; Xiangling Zeng; Sijia Zhou; Zhiwen Gu; Jiyang Pan
• Keywords: 03 medical and health sciences; 0302 clinical medicine; major depressive disorder; inflammation; high-sensitivity C-reactive protein; Neurosciences. Biological psychiatry. Neuropsychiatry; diffusion tensor imaging; white matter; RC321-571; Neuroscience; 3. Good health

Background Previous studies have noticed that systemic inflammation may alter the integrity of white matter. However, how levels serum cytokine affect matter in major depressive disorder (MDD) patients are unclear. Our study aimed to investigate association between inflammatory and microstructure drug-naïve with MDD pre- post-treatment. Method In total, 29 25 healthy controls (HC) were included this study. Diffusion tensor imaging (DTI) was conducted all subjects at baseline, reassessed after venlafaxine treatment, using a tract-based spatial statistics (TBSS) analysis. Morning interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), high-sensitivity C-reactive protein (hs-CRP) concentrations also measured Results Significantly reduced fractional anisotropy (FA) values found bilateral superior fronto-occipital fasciculus (SFO), posterior limb internal capsule (IC-PL), fornix compared HC, FA these regions risen normal except SFO treatment. The value left IC-PL inversely correlated peripheral hs-CRP both post-treatment patients. Conclusion results suggested significantly