Neuroprotective effects of resistance physical exercise on the APP/PS1 mouse model of Alzheimer’s disease

• DOI: 10.3389/fnins.2023.1132825
• Publication Date: 2023-04-06T04:53:15Z
• Authors: Henrique Correia ...; Deidiane Elisa Ri...; Debora Hashiguchi; Talita Glaser; Milena da Silva M...; Christiane Gimenes; Deborah Suchecki; Ricardo Mario Arida; Henning Ulrich; Beatriz Monteiro ...
• Keywords: Physical exercise

Introduction Physical exercise has beneficial effects by providing neuroprotective and anti-inflammatory responses to AD. Most studies, however, have been conducted with aerobic exercises, few investigated the of other modalities that also show positive on AD, such as resistance (RE). In addition its benefits in developing muscle strength, balance muscular endurance favoring improvements quality life elderly, RE reduces amyloid load local inflammation, promotes memory cognitive improvements, protects cortex hippocampus from degeneration occurs Similar AD patients, double-transgenic APPswe/PS1dE9 (APP/PS1) mice exhibit Αβ plaques hippocampus, hyperlocomotion, deficits, exacerbated inflammatory response. Therefore, aim this study was investigate 4 weeks intermittent training prevention recovery these AD-related neuropathological conditions APP/PS1 mice. Methods For purpose, 6-7-month-old male transgenic their littermates, negative for mutations (CTRL), were distributed into three groups: CTRL, APP/PS1, APP/PS1+RE. lasted four and, at end program, animals tested open field test locomotor activity object recognition evaluation. The brains collected immunohistochemical analysis Aβ microglia, blood plasma corticosterone ELISA assay. Results sedentary showed increased hippocampal higher levels, well hyperlocomotion reduced central crossings test, compared exercised control animals. program able recover behavioral, alterations CTRL levels. addition, protocol number microglial cells Despite alterations, no impairment observed novel test. Discussion Altogether, present results suggest plays a role alleviating symptoms, highlight complementary treatment