Altered metabolic-functional coupling in the epileptogenic network could predict surgical outcomes of mesial temporal lobe epilepsy

• DOI: 10.3389/fnins.2023.1165982
• Publication Date: 2023-06-08T05:01:20Z
• Authors: Siyu Yuan; Hui Huang; Bingyang Cai; Jiwei Li; Miao Zhang; Jie Luo
• Keywords: Anterior temporal lobectomy

To investigate the relationship between glucose metabolism and functional activity in epileptogenic network of patients with mesial temporal lobe epilepsy (MTLE) to determine whether this is associated surgical outcomes. 18F-FDG PET resting-state MRI (rs-fMRI) scans were performed on a hybrid PET/MR scanner 38 MTLE hippocampal sclerosis (MR-HS), 35 MR-negative 34 healthy controls (HC). Glucose was measured using standardized uptake value ratio (SUVR) relative cerebellum; Functional obtained by fractional amplitude low-frequency fluctuation (fALFF). The betweenness centrality (BC) metabolic covariance calculated graph theoretical analysis. Differences SUVR, fALFF, BC spatial voxel-wise SUVR-fALFF couplings network, consisting default mode (DMN) thalamus, evaluated Mann-Whitney U test (using false discovery rate [FDR] for multiple comparison correction). top ten selected Fisher score predict outcomes logistic regression model. results showed decreased coupling bilateral middle frontal gyrus (PFDR = 0.0230, PFDR 0.0296) MR-HS compared controls. Coupling ipsilateral hippocampus marginally increased 0.0802) along 0.0152; 0.0429). With ranking, regions from DMN thalamic subnuclei could best performance being combination an AUC 0.914. These findings suggest that altered neuroenergetic patients, which may provide insight into their pathogenesis help preoperative evaluation.