Aripiprazole disrupts cellular synchrony in the suprachiasmatic nucleus and enhances entrainment to environmental light–dark cycles in mice

• DOI: 10.3389/fnins.2023.1201137
• Publication Date: 2023-08-09T13:30:31Z
• Authors: Ruoshi Li; Kosaku Masuda; Daisuke Ono; Takashi Kanbayashi; Arisa Hirano; Takeshi Sakurai
• Keywords: Entrainment (biomusicology); Aripiprazole

Many patients with psychiatric conditions, such as bipolar disorder and major depressive disorder, frequently experience disruptions in their sleep–wake cycles. Several case studies clinical trials have shown that the administration of aripiprazole, a commonly prescribed antipsychotic drug, alleviates symptoms circadian sleep disorders these patients. This improvement may be attributed to effects aripiprazole on central clock, specifically hypothalamic suprachiasmatic nucleus (SCN), which regulates various physiological rhythms, including cycle, mammals. To examine whether facilitates adaptation changes light–dark we orally administered mice subjected them jet-lag experiments. Mice receiving were more rapidly entrained 6 h advanced Moreover, examined effect cellular rhythms SCN slice cultures found disrupted synchronization SCN, thereby accelerating damping rhythm at population level. Adenosine 3′5’ monophosphate (cAMP) assay using bioluminescence indicator revealed intracellular cAMP level increased following treatment. However, this increase was blocked by pre-treatment serotonin 1A receptor (5-HT R) antagonist. Based findings, propose modulates signaling, 5-HT R-mediated desynchronizes neurons, ultimately leading enhanced entrainment phase cycles mice. These findings indicate reported due modulation clock. Our study provides novel insights into potential applications disorders.