Association of IL6 and IL10 gene promotor polymorphisms with susceptibility to acute necrotizing encephalopathy

• DOI: 10.3389/fnins.2023.1231957
• Publication Date: 2023-08-03T12:42:04Z
• Authors: Ai Hoshino; Naoto Takahashi; Akira Oka; Masashi Mizuguchi
• Keywords: Pathogenesis

Acute necrotizing encephalopathy (ANE) is a severe complication of infectious diseases affecting the brain and systemic organs. The main pathogenesis cytokine storm, in which interleukin-6 (IL-6) interleukin-10 (IL-10) are candidates for key cytokines. To further elucidate their roles etiology ANE, we studied polymorphisms promotor regions IL6 IL10 genes by genetic functional analyses.We first conducted case-control association study four three polymorphisms. We genotyped 31 Japanese ANE cases compared results with those approximately 200 controls. For two showing possible association, next whether alter production IL-6 or IL-10 lymphoblasts upon phorbol 12-myristate 13-acetate (PMA) stimulation.The frequencies rs1800796G allele rs1800871/rs1800872 CC/CC diplotype were significantly higher than was associated low production, whereas GG genotype not production.IL10 may predispose children to altering early phase infection. Etio-pathogenetic significance remains be elucidated.