New insight on microglia activation in neurodegenerative diseases and therapeutics

• DOI: 10.3389/fnins.2023.1308345
• Publication Date: 2023-12-22T04:14:42Z
• Authors: Yucong Xu; Wei Gao; Yingnan Sun; Minghua Wu
• Keywords: 0301 basic medicine; 03 medical and health sciences; circadian rhythms; drug targets; microglia; neurodegenerative diseases; Neurosciences. Biological psychiatry. Neuropsychiatry; therapeutic approaches; central nervous system; RC321-571; Neuroscience

Microglia are immune cells within the central nervous system (CNS) closely linked to brain health and neurodegenerative diseases such as Alzheimer’s disease Parkinson’s disease. In response changes in surrounding environment, microglia activate change their state function. Several factors, example for circadian rhythm disruption development of diseases, influence activation. this review, we explore microglia’s function associated neural mechanisms. We elucidate that rhythms essential factors influencing activation Circadian affects and, consequently, diseases. addition, found abnormal is a common feature an factor development. Here highlight importance Targeting treatment promising direction. introduce progress methods targeting summarize drugs developed with targets, hoping provide new ideas treating