Polyphenol Extracts From Germinated Mung Beans Can Improve Type 2 Diabetes in Mice by Regulating Intestinal Microflora and Inhibiting Inflammation

• DOI: 10.3389/fnut.2022.846409
• Publication Date: 2022-03-29T09:19:21Z
• Authors: Xinting Shen; Xiujie Jiang; Lili Qian; Aiwu Zhang; Feng Zuo; Dongjie Zhang
• Keywords: Mung bean; Gut microflora

Studies have shown that inhibiting inflammation and regulating intestinal microflora imbalance is a significant factor in controlling the development of type 2 diabetes mellitus (T2DM). This experiment studied protective effect polyphenol extract from germinated mung beans on diabetic C57BL/6 mice. Results Fasting blood glucose (FBG) was decreased, tolerance increased, insulin resistance serum lipid indexes T2DM mice were improved, enzyme activities alanine aminotransferase (ALT) aspartate transaminase (AST) reduced. Meanwhile, levels interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) concentration 10 (IL-10) inflammatory reaction induced by repairing morphology liver tissue. At same time, bean (GMP) can regulate main flora, Firmicutes, Bacteroidetes, Proteobacteria also species diversity improve flora imbalance. Taken together, experimental conclusion certain dose mouse microflora.