Association of advanced lung cancer inflammation index with all-cause and cardiovascular mortality in US patients with rheumatoid arthritis

• DOI: 10.3389/fnut.2024.1397326
• Publication Date: 2024-05-30T04:51:09Z
• Authors: Zhuang Ma; Shixin Wu; Yitong Guo; Shiyi Ouyang; Ningning Wang
• Keywords: advanced lung cancer inflammation index; rheumatoid arthritis; 03 medical and health sciences; 0302 clinical medicine; cardiovascular mortality; Nutrition. Foods and food supply; all-cause mortality; NHANES; TX341-641; Nutrition

Introduction As a systemic autoimmune disorder, the prognosis of rheumatoid arthritis (RA) is intricately linked to inflammation. This study aimed investigate association between advanced lung cancer inflammation index (ALI), comprehensive indicator combined with nutritional status, and all-cause cardiovascular mortality among patients diagnosed RA. Methods The 2,305 RA from NHANES (2001–2018) included in analysis were categorized into three groups according ALI tertiles. Weighted Kaplan–Meier multivariate COX regression analyses evaluated relationship mortality. time-dependent characteristic curve (ROC) was used assess prediction accuracy ALI. Results During median follow-up 7.92 years, 591 participants died all causes, including 197 diseases. Increased associated decreased probability death. full model revealed lower hazard risks T2 (HR: 0.67, 95%CI: 0.54–0.83) T3 0.47 0.33–0.67, p for tend <0.001) compared T1, risk also 0.47, 0.31–0.70) 0.34, 0.19–0.62, trend <0.001). Furthermore, ROC underscored strong predictive capability (AUC 1-year 0.73 0.79, respectively). Conclusion cohort demonstrated higher predicting patients, highlighting important clinical value assessment evaluation.