Upregulated Expression of Cancer-Derived Immunoglobulin G Is Associated With Progression in Glioma

• DOI: 10.3389/fonc.2021.758856
• Publication Date: 2021-10-25T12:52:30Z
• Authors: Guohui Wang; Haonan Li; Jie Pan; Tianfang Yan; Huandi Zhou; Xuetao Han; Linlin Su; Liubing Hou; Xiaoying Xue
• Keywords: Tumor progression

Gliomas are the most aggressive intracranial tumors accounting for vast majority of brain with very poor prognosis and overall survival (OS). Cancer-derived immunoglobulin G (cancer-IgG) has been found to be widely expressed in several malignancies such as breast cancer, colorectal lung cancer. Cancer-IgG could promote tumorigenesis progression. However, its role glioma not revealed yet.We mined open databases including Chinese Glioma Genome Atlas (CGGA), The Cancer (TCGA), Gene Expression Omnibus (GEO) study IGHG1, which encodes cancer-IgG glioma. Examination differential expression IGHG1 was carried out GEO TCGA databases. Furthermore, different molecular subtypes analyzed. Stratified analysis performed clinical features. Subsequently, immune infiltration conducted using single-sample gene set enrichment (ssGSEA). GSEA reveal mechanisms IGHG1. Lastly, immunohistochemistry processed validate our findings.In this study, we that higher prognosis. patients a high worse stratified analysis. Immune indicated level positively correlated stromal score, ESTIMATE score negatively tumor purity. Results from DAVID demonstrated may function phagosome, antigen processing presentation, extracellular matrix structural constituent, binding, collagen-containing matrix. Finally, assay validated findings had OS disease-free (DFS).Cancer-IgG is promising biomarker diagnosis treatment