FBXW7 and Its Downstream NOTCH Pathway Could be Potential Indicators of Organ-Free Metastasis in Colorectal Cancer

• DOI: 10.3389/fonc.2021.783564
• Publication Date: 2022-06-01T08:23:22Z
• Authors: Dongzheng Li; Shiye Jiang; Xin Zhou; Chengshuai Si; Peng Shao; Qian Jiang; Liuqing Zhu; Lu Shen; Qi Meng; Jiani C. Yin; Yang Shao; Yueming Sun; Liu Yang
• Keywords: 0301 basic medicine; NOTCH; 03 medical and health sciences; Oncology; FBXW7; organ metastasis; NGS; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; colorectal cancer; RC254-282; 3. Good health

Colorectal cancer (CRC) is one of the leading causes cancer-related deaths globally. Metastasis associated with a poor prognosis, yet underlying molecular mechanism(s) remained largely unknown. In this study, total 85 CRC patients were included and primary tumor lesions evaluated by next-generation sequencing using targeted panel for genetic aberrations. Patients sub-divided according to their metastasis pattern into non-organ metastases (Non-OM) organ (OM) groups. By comparing differences between two groups, we found that mutations in FBXW7 alterations its downstream NOTCH signaling pathway more common Non-OM group. Moreover, correlation analysis suggested independent other somatic alterations. The negative associations validated cohort 230 TCGA dataset. Thus, speculated genomic / axis might be an indicator metastases.