Acidic Urine Is Associated With Poor Prognosis of Upper Tract Urothelial Carcinoma

• DOI: 10.3389/fonc.2021.817781
• Publication Date: 2022-01-24T05:19:46Z
• Authors: Jang Hee Han; Seung-hwan Jeong; Hyeong Dong Yuk; Chang Wook Jeong; Cheol Kwak; Ja Hyeon Ku
• Keywords: Lymphovascular invasion; Upper urinary tract

To assess the prognostic role of acidic urine (low pH) in upper tract urothelial cancer (UTUC).We reviewed patients enrolled Seoul National University Prospectively Enrolled Registry for Urothelial Cancer-Upper Tract Cancer (SUPER-UC-UTUC) who underwent surgical resection from March 2016 to December 2020 Hospital (SNUH). Patients with non-urothelial or those are condition at end-stage renal disease were excluded. Acidic was defined as pH ≤ 5.5.A total 293 a mean age 70.7 ± 9.5 years this study. Pre-operative laboratory results showed estimated glomerular filtration rate (eGFR) 64.1 19.2 mL/min/1.73m2 and 5.86 0.66. subdivided into low (pH 5.5) high > comparison. As result, all variables comparable except T stage, which significantly higher group (p = 0.017). Cox regression analysis performed clinical impact on patient survival. Multivariate revealed that tumor multifocality (HR 2.07, p 0.015), stage 1.54, 0.036), lymphovascular invasion 1.69, 0.033), eGFR < 60 mL/min per 1.73 m2 1.56, 0.017), 1.63, 0.01) independently decreased disease-free survival (DFS), while 9.50, 0.01), 9.51, 0.001) 10.36, 0.004) reduced overall (OS).Acidic is associated DFS OS UTUC. contributing environment may promote acquisition agressive behavior