PET/MR Imaging of Somatostatin Receptor Expression and Tumor Vascularity in Meningioma: Implications for Pathophysiology and Tumor Outcomes

• DOI: 10.3389/fonc.2021.820287
• Publication Date: 2022-01-28T12:07:34Z
• Authors: Michelle Roytman; Sean Kim; Shannon Glynn; Charlene Thomas; Eaton Lin; Whitney Feltus; Rajiv S. Magge; Benjamin Liechty; Theodore H. Schwartz; Rohan Ramakrishna; Nicolas A. Karaka...; Susan C. Pannullo; Joseph R. Osborne; Jonathan P. S. Kn...; Jana Ivanidze
• Keywords: Pathophysiology; Vascularity

Meningiomas, the most common primary intracranial tumor, are vascular neoplasms that express somatostatin receptor-2 (SSTR2). The purpose of this investigation was to evaluate if a relationship exists between tumor vascularity and SSTR2 expression, which may play role in meningioma prognostication clinical management. Gallium-68-DOTATATE PET/MRI with dynamic contrast-enhanced (DCE) perfusion prospectively performed. Clinical demographic patient characteristics were recorded. Tumor volumes segmented superimposed onto parametric DCE maps including flux rate constant (Kep), transfer (Ktrans), extravascular volume fraction (Ve), plasma (Vp). Meningioma PET standardized uptake value (SUV) SUV ratio superior sagittal sinus (SUVRSSS) Pearson correlation analyses In random subset, analysis repeated by second investigator, intraclass coefficients (ICCs) determined. Thirty-six patients 60 meningiomas (20 WHO-1, 27 WHO-2, 13 WHO-3) included. Mean Kep demonstrated strong significant positive (r = 0.84, p < 0.0001) SUVRSSS 0.81, 0.0001). When stratifying WHO grade, persisted WHO-2 0.91, WHO-3 0.92, 0.0029) but not WHO-1 0.26, 0.4, SUVRSSS). ICC excellent (0.97-0.99). DOTATATE expression WHO-3, meningiomas, suggesting biological differences higher-grade predictive will be tested future work.