Diagnostic performance of six ultrasound-based risk stratification systems in thyroid follicular neoplasm: A retrospective multi-center study

• DOI: 10.3389/fonc.2022.1013410
• Publication Date: 2022-10-20T11:50:24Z
• Authors: Jingjing Yang; Yu Sun; Xingjia Li; Yueting Zhao; Xue Han; Guofang Chen; Wenbo Ding; Ruiping Li; Jianhua Wang; Fangsen Xiao; Chao Liu; Shuhang Xu
• Keywords: Thyroid Nodules; Risk Stratification

This study aimed to compare the diagnostic performances of six commonly used ultrasound-based risk stratification systems for distinguishing follicular thyroid adenoma (FTA) from carcinoma (FTC), including American Thyroid Association Sonographic Pattern System (ATASPS), ultrasound classification proposed by Clinical Endocrinologists, College Endocrinology, and Associazione Medici Endocrinology (AACE/ACE/AME), Korean imaging reporting data system (K-TIRADS), European (EU-TIRADS), Radiology (ACR-TIRADS), 2020 Chinese Guidelines Ultrasound Malignancy Risk Stratification Nodules (C-TIRADS). A total 225 FTA or FTC patients were retrospectively analyzed, involving 251 nodules diagnosed postoperative pathological examinations in three centers January 2013 October 2021. The assessed plotting receiver operating characteristic (ROC) curves compared at different cut-off values. 205 (81.67%) cases 46 (18.33%) involved present study. Compared with those FTA, presented more typical features solid component, hypoechoic, irregular margin sonographic halo (all P<0.001). There no significant differences calcification, shape comet-tail artifacts between FTC. was a difference category (P<0.001). areas under curve (AUCs) ATASPS, AACE/ACE/AME, K-TIRADS, EU-TIRADS, ACR-TIRADS C-TIRADS 0.645, 0.729, 0.766, 0.635, 0.783 0.798, respectively. Our demonstrated that all potential differential diagnosis Specifically, exerts best performance among patients. ATASPS possesses high sensitivity, while K-TIRADS specificity