Role of inflammatory factors in prediction of Gleason score and its upgrading in localized prostate cancer patients after radical prostatectomy

• DOI: 10.3389/fonc.2022.1079622
• Publication Date: 2023-01-12T06:30:24Z
• Authors: Shuo Wang; Yongpeng Ji; Jinchao Ma; Peng Du; Yudong Cao; Xiao Yang; Ziyi Yu; Yong Yang
• Keywords: Prostate biopsy; Univariate analysis; Mean platelet volume; Nomogram

To investigate the role of inflammatory factors including systemic immune-inflammation index (SII) and neutrophil to lymphocyte ratio (NLR) in predicting Gleason Score (GS) upgrading (GSU) localized prostate cancer (PCa) after radical prostatectomy (RP).The data 297 patients who underwent biopsy RP our center from January 2014 March 2020 were retrospectively analyzed. Preoperative clinical characteristics age, values tPSA, total volume (TPV), f/t PSA ratio, body mass (BMI), GS SII, NLR, monocyte (LMR), (NR), platelet (PLR), (LR), mean (MPV) red cell distribution (RDW) as well pathological T (pT) stage collected compared according grades (GS ≤ 6 GS≥7), respectively. ROC curve analysis was used confirm discriminative ability NLR their combination with tPSA for GSU. By using univariate multivariate logistic regression analysis, association between significant markers evaluated.Patients enrolled divided into low 6) high (GS≥7) groups by GS. The median 66.08 ± 6.04 years 36.62 23.15 mL TPV, 26.16 33.59 ng/mL 0.15 0.25 22.34 3.14 kg/m2 BMI, 15 (5.1%) pT1, 116 (39.1%) pT2 166 (55.9%) pT3. According student's t test, group had a greater proportion pT3 (P<0.001), higher (P=0.04), SII (P=0.037) (P=0.015) group, LMR, NR, PLR, LR, MPV RDW did not show any significantly statistical differences. AUC 0.732 (P=0.007), 0.649 (P=0.045) 0.711 (P=0.015), threshold 51l.08, 2.3 10.31ng/mL, multivariable models, ≥ (OR, 2.463; 95% CI, 0.679-10.469, P=0.042), 511.08 3.519; CI 0.891-12.488; P=0.003) 10.31 4.146; 1.12-15.35; P=0.033) all independent risk associated 0.758 (P=0.003) 0.756 (P=0.003), GSU observed 48 (55.17%). Then 2 (high low) value SII+tPSA NLR+tPSA, respectively, when rates regard these factors, rate level than that P=0.001, 0.044, 0.017, <0.001 <0.001, respectively.High rate. likely be more favorable biomarker it largest area NLR; or alone, since much higher. useful biomarkers detecting among PCa 6.