Lymph node metastasis is not associated with survival in patients with clinical stage T4 esophageal squamous cell carcinoma undergoing definitive radiotherapy or chemoradiotherapy

• DOI: 10.3389/fonc.2022.774816
• Publication Date: 2022-09-13T08:41:24Z
• Authors: Liqiong Zhu; Zongxing Zhao; Ao Liu; Xin Wang; Xiaotao Geng; Yu Nie; Fen Zhao; Minghuan Li
• Keywords: Chemoradiotherapy

Clinical T4 stage (cT4) esophageal tumors are difficult to be surgically resected, and definitive radiotherapy (RT) or chemoradiotherapy (dCRT) remains the main treatment. The study aims analyze association between status of lymph node (LN) metastasis survival outcomes in cT4 squamous cell carcinoma (ESCC) patients that underwent treatment with dCRT RT. This retrospective analyzed clinical data 555 ESCC treated RT at Shandong Cancer Hospital Liaocheng People's from 2010 2017. Kaplan-Meier Cox regression analyses was performed determine relationship LN non-cT4 patients. chi-square test used evaluate differences local distal recurrence patterns belonging various T stages. 3-year rates for were 47.9% 30.8%, respectively. overall (OS) progression-free (PFS) strongly associated entire cohort (all P < 0.001) group but not group. 60.7% 45.1% (P 0.001). Multivariate analysis showed N = 0.002), size 0.007), abdominal involvement 0.011) independent predictors favorable OS However, 0.824), 0.383), 0.337) did show any significant correlation Our demonstrated correlate received Furthermore, prevalence higher