MSLN Correlates With Immune Infiltration and Chemoresistance as a Prognostic Biomarker in Ovarian Cancer

• DOI: 10.3389/fonc.2022.830570
• Publication Date: 2022-05-25T05:49:33Z
• Authors: Yike Li; Wanjia Tian; Hong Zhang; Zhijian Zhang; Qinghe Zhao; Lei Chang; Ningjing Lei; Weiwei Zhang
• Keywords: Mesothelin

Mesothelin (MSLN) is a glycoprotein with various expression degrees in different tumors including mesothelioma, ovarian cancer, pancreatic etc. MSLN considered to play an important role cell survival, proliferation, and tumor progression. Although the of makes it potential therapeutic target, its mechanism action still unclear, especially correlation immune cells infiltration microenvironment has not been investigated. In this study, we detected overexpression cancer using database analysis tissue-array staining. We further evaluated diagnostic value found was associated poor overall survival cancer. addition, high significantly related immune-related genes chemoresistant genes. confirmed lines. Our research suggests that participates variety pathways suppression activation promotion chemoresistance, leading prognosis