Trends in Disease Burden of Chronic Lymphocytic Leukemia at the Global, Regional, and National Levels From 1990 to 2019, and Projections Until 2030: A Population-Based Epidemiologic Study

• DOI: 10.3389/fonc.2022.840616
• Publication Date: 2022-03-10T15:01:01Z
• Authors: Yang Ou; Yichen Long; Lili Ji; Yanxia Zhan; Tiankui Qiao; Xiangdong Wang; Hao Chen; Yunfeng Cheng
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Oncology; death; incidence; chronic lymphocytic leukemia; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; epidemiology; disability-adjusted life years; RC254-282; 3. Good health

Background The prognosis of chronic lymphocytic leukemia (CLL) has been improved dramatically, but there are limited studies focusing on CLL disease burden a global scale. We aimed to evaluate the accurate assessment that may provide more detailed epidemiological information for rational policies. Methods main source data was Global Burden Disease (GBD) study 2019. Incident cases, death disability-adjusted life years (DALYs), and their corresponding age-standardized rates (ASRs) from 1990 2019 were used describe CLL. Data about attributable risk factors also extracted analyzed. Bayesian age-period-cohort (BAPC) models assess project incidence mortality till 2030. Results Globally, had increasing. Deaths DALYs decreased slightly. DALY is affected by socio-demographic index (SDI). rate, rate increased significantly with age. Male-to-female ratios varied in different SDI quintiles. Smoking, high body mass index, occupational exposure benzene or formaldehyde potential related ASIRs might tend increase until 2030, while ASDR would decrease Conclusion higher countries lower ones. Strategies early detection asymptomatic CLL, development novel drugs, measures against should be implemented combat burden.