Eosinophils Decrease Pulmonary Metastatic Mammary Tumor Growth

• DOI: 10.3389/fonc.2022.841921
• Publication Date: 2022-06-08T04:51:55Z
• Authors: Rachel A. Cederberg; Sarah Elizabeth F...; Brennan J. Wadsworth; Alvina So; Lisa R. Decotret; Michael G. Hall; Rocky Shi; Michael R. Hughes; Kelly M. McNagny; Kevin L. Bennewith
• Keywords: Eosinophil peroxidase; Mammary tumor

Metastatic breast cancer is challenging to effectively treat, highlighting the need for an improved understanding of host factors that influence metastatic tumor cell colonization and growth in distant tissues. The lungs are a common site metastasis population tissue-resident eosinophils. Eosinophils granulocytic innate immune cells known their prominent roles allergy Th2 immunity. Though presence solid tumors metastases have been reported decades, eosinophils on unclear. We used transgenic mouse models characterized by elevated pulmonary (IL5Tg mice) eosinophil-deficiency (ΔdblGATA mice), as well antibody-mediated depletion eosinophils, study role EO771 mammary lungs. found IL5Tg mice exhibit reduced decreased burden compared wild-type (WT) or eosinophil-deficient mice. co-cultured with ex vivo produced peroxidase activity induced death, indicating capable releasing eosinophil (EPX) killing cells. lung expressed phenotypic markers activation during lungs, was accelerated WT after immunological Our results highlight important restricting support further work determine whether strategies trigger local degranulation may decrease growth.