Socioeconomic, Clinical, and Molecular Features of Breast Cancer Influence Overall Survival of Latin American Women

• DOI: 10.3389/fonc.2022.845527
• Publication Date: 2022-06-17T14:24:25Z
• Authors: Liz Maria de Almeida; Sandra Cortés; Marta Vilensky; Olivia Valenzuela; Laura Cortes-Sana...; Mirian de Souza; Rafael Alonso Bar...; Eliana Abdelhay; Nora Artagaveytia; Adrian Daneri-Nav...; Andrea S. Llera; Bettina Müller; Osvaldo L. Podhajcer; Carlos Velazquez; Elsa Alcoba; Isabel Alonso; Alicia I. Bravo; Natalia Camejo; Dirce Maria Carraro; Mónica Castro; Sandra Cataldi; Alfonso Cayota; Mauricio Cerda; Alicia Colombo; Susanne Crocamo; Alicia Del Toro-A...; Raul Delgadillo-C...; Lucia Delgado; Marisa Dreyer Bre...; Elmer Fernández; Jorge Fernández; Wanda Fernández; Ramon A. Franco-T...; Fancy Gaete; Jorge Gómez; Leivy P. Gonzalez...; Marisol Guerrero; Susan A. Gutierre...; Beatriz Jalfin; Alejandra Lopez-V...; Dora Loria; Silvia Míguez; Andres de J. Mora...; Gilberto Morgan-V...; Carina Mussetti; Maria Aparecida N...; Antonio Oceguera-...; Rui M. Reis; Javier Retamales; Robinson Rodriguez; Cristina Rosales; Efrain Salas-Gonz...; Laura Segovia; Juan M. Sendoya; Aida A. Silva-Garcia; Stella Viña; Livia Zagame; Beth Jones; Moysés Szklo
• Keywords: Medical Sciences; Biochemical Phenomena; Molecular subtypes; Global excellence; 610; Biomedical Informatics; 03 medical and health sciences; Breast cancer; breast cancer; 0302 clinical medicine; 03 Salud y bienestar; Medical Specialties; Medicine and Health Sciences; risk factors; RC254-282; and Nutrition; molecular subtypes; Tecnología; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; 600; R Medicina (General); Prognosis; 03 Good health and well-being; Metabolism; Latin America; Risk factors; Oncology; Medical Microbiology; oncology; global excellence; prognosis; RC0254 Neoplasias. Los tumores. Oncología (incluyendo cáncer)

Molecular profile of breast cancer in Latin-American women was studied five countries: Argentina, Brazil, Chile, Mexico, and Uruguay. Data about socioeconomic characteristics, risk factors, prognostic molecular subtypes were described, the 60-month overall cumulative survival probabilities (OS) estimated. From 2011 to 2013, 1,300 eligible 18 years or older, with a diagnosis clinical stage II III, performance status ≦̸1 invited participate prospective cohort study. Face-to-face interviews conducted, outcome data, including death, extracted from medical records. Unadjusted associations evaluated by Chi-squared Fisher's exact tests OS Kaplan-Meier method. Log-rank test used determine differences between probability curves. Multivariable adjustment carried out entering potential confounders Cox regression model. The at 60 months 83.9%. Multivariable-adjusted death hazard found for living Argentina (2.27), Chile (1.95), Uruguay (2.42) compared Mexican women, older (≥60 years) (1.84) younger (≤40 basal-like subtype (5.8), luminal B (2.43), HER2-enriched (2.52) A subtype, tumor stages IIB (1.91), IIIA (3.54), IIIB (3.94) IIA women. associated country residence, PAM50 intrinsic age, diagnosis. While latter is known be influenced access care, screening, timely treatment, more effective treatment protocols, it may also influence epigenetic changes that, potentially, impact subtypes. derived heretofore understudied populations unique geographic ancestry sociocultural experiences are critical furthering our understanding this complexity.