Adjuvant Radiotherapy Versus Surveillance for Grade 2 Intracranial Meningiomas: A Multi-Institutional Propensity Score-Matched Study

• DOI: 10.3389/fonc.2022.877244
• Publication Date: 2022-07-01T04:39:35Z
• Authors: Hwa Kyung Byun; Won Ick Chang; Joo Ho Lee; Chul-Kee Park; In Ah Kim; Chae-Yong Kim; Jaeho Cho; Eui Hyun Kim; Jong Hee Chang; Seok-Gu Kang; Ju Hyung Moon; Sang Hyung Lee; Jason Joon Bock Lee; Il Han Kim; Chang-Ok Suh; Chan Woo Wee; Hong In Yoon
• Keywords: Adjuvant radiotherapy

We aimed to compare the outcomes of adjuvant radiotherapy (ART) and surveillance in patients with grade 2 meningiomas (MNG2) who underwent surgical resection. Data from four hospitals, which aged ≥18 years Simpson 1-4 resection for newly diagnosed MNG2 between 1998 2018, were examined this multicenter retrospective cohort study. Patients receiving ART conventional fractionation compared those undergoing surveillance. Progression-free survival (PFS), progression/recurrence (P/R) evaluated. This study included 518 patients, 158 whom received ART. The median follow-up duration was 64.9 months. In total cohort, independently associated significantly improved PFS (HR, 0.35; 95% CI, 0.23-0.55; P<0.001) P/R 0.30; 0.18-0.48; P<0.001). propensity score-matched (n=143 each group), 5-year rates 80.8% 57.7% (P=0.004), 16.5% 40.0% (P=0.002) groups, respectively. After gross resection, (85.0% vs. 64.7%; P=0.020) (15.2% 32.0%; P=0.035) better group than group. A model developed using recursive partitioning analysis extent, tumor size, Ki-67 index. reduced risk low- (P=0.069), intermediate- (P=0.044), high-risk groups (P<0.001). Local control also enhanced by among all (all P<0.05). MNG2, irrespective can be recommended after prognostic may guide decision-making use