PDPN marks a subset of aggressive and radiation-resistant glioblastoma cells

• DOI: 10.3389/fonc.2022.941657
• Publication Date: 2022-08-10T06:52:21Z
• Authors: Aram S. Modrek; Eskil Eskilsson; Ravesanker Ezhila...; Qianghu Wang; Lindsey D. Goodman; Yingwen Ding; Ze-Yan Zhang; Krishna P. L. Bhat; Thanh-Thuy T. Le; Floris P. Barthel; Ming Tang; Jie Yang; Lihong Long; Joy Gumin; Frederick F. Lang; Roel G. W. Verhaak; Kenneth D. Aldape; Erik P. Sulman
• Keywords: Podoplanin; Clonogenic assay

Treatment-resistant glioma stem cells are thought to propagate and drive growth of malignant gliomas, but their markers our ability target them specifically not well understood. We demonstrate that podoplanin (PDPN) expression is an independent prognostic marker in gliomas across multiple patient cohorts comprising both high- low-grade gliomas. Knockdown PDPN radiosensitized cell lines glioma-stem-like (GSCs). Clonogenic assays xenograft experiments revealed was associated with radiotherapy resistance tumor aggressiveness. further knockdown GSCs vivo sufficient improve overall survival intracranial mouse model. therefore identifies a subset aggressive, treatment-resistant responsible for radiation may serve as novel therapeutic target.