Comprehensive analysis of alfa defensin expression and prognosis in human colorectal cancer

• DOI: 10.3389/fonc.2022.974654
• Publication Date: 2023-01-10T21:36:26Z
• Authors: Xinliang Zhao; Mengnan Lu; Zhigang Liu; Mingming Zhang; Hongmei Yuan; Zhaoqiang Dan; Daihua Wang; Bingbing Ma; Yanqi Yang; Funing Yang; Ruifang Sun; Lin Li; Chengxue Dang
• Keywords: 0301 basic medicine; 03 medical and health sciences; Oncology; expression; biomarker; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; colorectal cancer; prognosis; defensin; RC254-282; 3. Good health

Introduction Colorectal cancer (CRC) is a serious threat to human health. Screening new biomarkers can provide basis for improving the prognosis and individualized treatment of CRC. Although some members defensin family were found increased in pancreatic CRC, their exact function clinical significance remain unclear. Methods In this study, expression, correlation, mutation, functional enrichment several CRC analyzed using tumor public databases verified patients. Results showed no significant correlation between expression levels DEFA1-4 The DEFA5 DEFA6 significantly tissues compared with those normal tissues. may be associated better while poor prognosis. Immunohistochemistry (IHC) experiments that was higher adenoma than mucosa slightly carcinoma mucosa. Kyoto Encyclopedia Genes Genomes (KEGG) analysis DEFAs closely related hsa05202: transcriptional misregulation Hsa04015: Rap1 signaling pathway. stable good prognostic marker, marker metastasis. Conclusion Overall, have certain degree sensitivity specificity predicting