Combining prognostic nutritional index (PNI) and controlling nutritional status (CONUT) score as a valuable prognostic factor for overall survival in patients with stage I–III colorectal cancer

• DOI: 10.3389/fonc.2023.1026824
• Publication Date: 2023-01-30T08:27:23Z
• Authors: Harin Kim; Dong-Min Shin; Jae-Hoon Lee; Eun-Suk Cho; Hye Sun Lee; Su-Jin Shin; Eun Jung Park; Seung Hyuk Baik; Kang Young Lee; Jeonghyun Kang
• Keywords: 2. Zero hunger; 610; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; colorectal cancer; inflammatory marker; 3. Good health; prognostic nutritional index (PNI); 03 medical and health sciences; 0302 clinical medicine; Oncology; 616; controlling nutritional status (CONUT) score; prognostic factor; RC254-282

Background and aims This study compared the prognostic significance of various nutritional inflammatory indicators such as neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio platelet-to-lymphocyte index, controlling status score. In addition, we aimed to establish a more accurate indicator. Methods We retrospectively evaluated 1112 patients with stage I–III colorectal cancer between January 2004 April 2014. The scores were classified low (0–1), intermediate (2–4), high (5–12) scores. cut-off values for index markers calculated using X-tile program. P-CONUT, combination score, was suggested. integrated areas under curve then compared. Results multivariable analysis showed that an independent factor overall survival, whereas not. divided into three P-CONUT groups follows: G1, (0–4) index; G2, G3, index. There significant survival differences (5-year G3 91.7%, 81.2%, 64.1%, respectively; p < 0.0001). (0.610, CI: 0.578–0.642) superior those score alone (bootstrap mean difference=0.050; 95% CI=0.022–0.079) difference=0.012; CI=0.001–0.025). Conclusion Prognostic effect may be better than ratio. Thus, it could used reliable risk stratification tool in cancer.