Evaluation of thromboembolic event, basic coagulation parameters, and associated factors in patients with colorectal cancer: a multicenter study

• DOI: 10.3389/fonc.2023.1143122
• Publication Date: 2023-05-02T20:37:00Z
• Authors: Fitalew Tadele Ad...; Tadesse Asmamaw D...; Gashaw Walle Ayehu; Edget Abebe Zewde; Gashaw Dessie; Dagnew Getnet Adugna; Engidaw Fentahun ...; Zeleke Geto; Endeshaw Chekol A...
• Keywords: Interquartile range

Patients with colorectal cancer are at an increased risk of hemostatic disturbances, and recent studies have shown that coagulation disorders could be the first sign malignancy. Although coagulopathy is a significant cause cancer-related death disability, it usually underestimated, there has been no scientific evidence regarding exact burden its specific determinants. Moreover, public health importance among patients polyps not addressed.An institution-based comparative cross-sectional study was conducted on total 500 participants (250 patients, 150 polyp 100 controls) from January to December 2022. Venous blood collected for basic platelet analysis. Descriptive statistics non-parametric tests (Kruskal-Wallis Dunn-Bonferroni pairwise comparisons) were used compare parameters groups. The test results expressed as medians interquartile ranges. Binary logistic regressions fitted, statistical significance declared p-value less than 0.05, 95% CI.The prevalence 198 (79.2%; CI: 73.86, 83.64), while 76 (50.7%; 45.66, 54.34) patients. From final model, age between 61 70 (AOR = 3.13: 1.03, 6.94), > years 2.73: 1.08, 4.71), hypertension 6.8: 1.07, 14.1), larger tumor size 3.31: 1.11, 6.74), metastatic 5.8: 1.1, 14.7), BMI ≥30 kg/m2 3.8: 2.3, 4.8) positively associated coagulopathy.This showed major concern cancer. Therefore, existing oncology care efforts should strengthened prevent receive more attention.