The MANGO study: a prospective investigation of oxygen enhanced and blood-oxygen level dependent MRI as imaging biomarkers of hypoxia in glioblastoma

• DOI: 10.3389/fonc.2023.1306164
• Publication Date: 2023-12-22T03:04:28Z
• Authors: Caterina Brighi; David E. J. Waddi...; Paul J. Keall; Jeremy Booth; Kieran O’Brien; Shona Silvester; Jonathon Parkinson; Marco Mueller; Jackie Yim; Dale L. Bailey; Michael Back; James Drummond
• Keywords: Hypoxia; Tumor Hypoxia; Blood-oxygen-level dependent; Clinical endpoint; Imaging biomarker

Background Glioblastoma (GBM) is the most aggressive type of brain cancer, with a 5-year survival rate ~5% and tumours recurring locally within months first-line treatment. Hypoxia associated worse clinical outcomes in GBM, as it leads to localized resistance radiotherapy subsequent tumour recurrence. Current standard care treatment does not account for hypoxia, due challenges mapping hypoxia routine practice. In this study, we aim investigate role oxygen enhanced (OE) blood-oxygen level dependent (BOLD) MRI non-invasive imaging biomarkers evaluate their potential dose-painting planning response assessment. Methods The primary endpoint quantitative spatial correlation between OE BOLD measurements [ 18 F]MISO values uptake tumour. secondary endpoints are repeatability test-retest estimate benefits using guide radiotherapy, ability assess response. Twenty newly diagnosed GBM patients will be enrolled study. Patients undergo while receiving additional OE/BOLD PET scans at several timepoints during map hypoxic regions evaluated by assessing correlations areas identified via imaging. Discussion MANGO (Magnetic resonance radiation guidance glioblastoma multiforme) diagnostic/prognostic study investigating management. generate large amount longitudinal multimodal data that could used unveil dynamic changes physiology currently limit efficacy, thereby providing means develop more effective personalised treatments.