Predicting the status of lymphovascular space invasion using quantitative parameters from synthetic MRI in cervical squamous cell carcinoma without lymphatic metastasis

• DOI: 10.3389/fonc.2024.1304793
• Publication Date: 2024-02-06T04:56:46Z
• Authors: Limei Guo; Runmei Zhang; Yi Xu; Wenqi Wu; Qian Zheng; Jianting Li; Jun Wang; Jinliang Niu
• Keywords: Lymphovascular invasion

Purpose To investigate the value of quantitative longitudinal relaxation time (T1), transverse (T2), and proton density (PD) maps derived from synthetic magnetic resonance imaging (MRI) for evaluating status lymphovascular space invasion (LVSI) in cervical squamous cell carcinoma (CSCC) without lymph node metastasis (LNM). Material methods Patients with suspected cancer who visited our hospital May 2020 to March 2023 were collected. All patients underwent preoperative MRI, including routine sequences MRI. pathologically confirmed CSCC lymphatic included this study. The subjects divided into negative- positive-LVSI groups based on LVSI. Quantitative parameters T1, T2, PD values MRI compared between two using independent samples t -test. Receiver operating characteristic curves used determine diagnostic efficacy parameters. Results 59 enrolled study classified as positive (n = 32) negative LVSI 27). T1 T2 showed significant differences differentiating negative-LVSI (1307.39 ± 122.02 vs. 1193.03 107.86, P <0.0001; 88.42 7.24 80.99 5.50, <0.0001, respectively). area under curve (AUC) a combination 0.756, 0.799, 0.834 respectively, there is no statistically difference individual combined diagnosis each parameter. Conclusions can be evaluate LNM.